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Seneca is located in Oconee County, South Carolina. There are roughly 5,362 residents, living in 2,272 households. The average temperature for Seneca this time of the year is low of 47F and high of 73F. On average, Seneca gets about 3.87 inches of precipitation in April. Most residents are home owners (58%), have a high school diploma (52%) and are single, no kids (45%).