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Cape Girardeau is located in Cape Girardeau County, Missouri. There are roughly 35,187 residents, living in 13,937 households. The average temperature for Cape Girardeau this time of the year is low of 55F and high of 78F. On average, Cape Girardeau gets about 4.94 inches of precipitation in May. Most residents are home owners (52%), have a post secondary degree (49%) and are single, no kids (48%).