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Holtsville is located in Brookhaven, New York. There are roughly 19,730 residents, living in 6,711 households. The average temperature for Holtsville this time of the year is low of 49F and high of 68F. On average, Holtsville gets about 4.06 inches of precipitation in May. Most residents are home owners (80%), have a post secondary degree (52%) and are married, with kids (32%).